Preheat oven to 375 degrees.
Unroll crescent roll dough and press seams together to form a rectangle.
Cut the dough into 6 squares.
Spread 1 1/2 teaspoons of onion and chive cream cheese spread on each dough square. Leave a 1/4" border around the edges.
Place 2 slices of deli roast beef on top of cream cheese spread.
Top each square with 1/2 slice of provolone and 1/2 slice of cheddar.
Fold each square into a triangle and crimp the edges with a fork to seal.
Transfer hand pies to a parchment lined baking sheet.
In a small bowl, combine egg and water; brush egg wash on top of each hand pie.
Sprinkle dried oregano on top of each hand pie.
Bake for 14 minutes or until golden brown and cooked through.